buckster03 wrote:going into the cell stage I get a flashing screen (yellow, red, green, purple, etc). If I Ctrl + Alt + Del and select the task manager I can then go back into the game and play the cell stage all the way through.
Windows Vista 64-bit Ultimate SP1
Try disabling Vista's Aero interface, and closing any other app that might be accessing the 3D card. Windows Sidebar for one, anything that MIGHT be 3D. One very stupid app I learned uses the 3D card is AIM 5.1 - if you happen to be using that, completely close it out (check for it in Processes in the Task Manager and knock it out).
Once you've got absolutely nothing accessing the 3D features of the card, start up Spore and see if the situation improves. Just a hunch - I had a problem like this years ago on XP and it was because of 2 applications fighting over the 3D card.